SBE- Beta -CD is a polyanion derived beta cyclodextrin derivative with a round platform shape, a hydrophobic inside of the round platform, a hydrophilic sulfonyl ether substituent, and a better hydrophobic drug molecule in the internal and side chain of the round platform, which has the function and safety of increasing drug solubility, improving drug stability and so on. Good advantages, can improve the bioavailability of drugs, reduce adverse reactions, especially for the development of insoluble drug injections, and in other fields of pharmaceutical preparations have also been widely used.
Inclusion of hydrophobic groups of poorly soluble drugs enters the hydrophobic cavity of cyclodextrins under the stereostructure matching and the polarity of both. The combination of non covalent bonds between main molecules and guest molecules, such as dispersion force, gravitational force between dipole, hydrogen bond and charge transfer force, is generally a synergistic action of several forces, which is a physical dynamic equilibrium process. In dilute solution, inclusion is the main form or even the only form of binding between drugs and cyclodextrins. It is worth noting that the SBE- Beta -CD is different from other cyclodextrin derivatives, and the distance between the charged sulfonic group and the cyclodextrin matrix is far away, and does not fold into the cavities of cyclodextrin, thus affecting the hydrophobicity. And because the charges between sulfonic groups are excluded from each other, 1 hydrophobic regions, formed by the sulfonyl alkyl ether, are formed near the cyclodextrin cavity, which jointly participate in the inclusion of drug molecules.
Cyclodextrin Inclusion Compound Beta Cyclodextrin Polymer mainly including Cyclodextrin Inclusion Compound and Beta cyclodextrin polymer crosslinked with epichlorohydrin.
Name : Beta cyclodextrin polymer crosslinked with epichlorohydrin
CAS: 25655-42-9
Other name : β-Cyclodextrin polymer with 2-(chloromethyl)oxirane
Chemical Formula :(C42H70O35)n (C3H6O)m
Purity : >98%
Package: 2g/bag, 3g/bag ,5g/bag ,10g/bag or customized
Storage: at room temperature, in tightly closed container. Avoid light .
Use: REAGENT
Cyclodextrin Complex mainly including Piroxicam Beta Cyclodextrin Complex, Azelaic acid Hydroxypropyl Beta Cyclodextrin complex, Menthol beta hydroxypropyl beta cyclodextrin complex and Vanillin beta cyclodextrin complex.
Piroxicam Beta Cyclodextrin is made by enwrapping medical piroxicam and medical beta-cyclodextrin in a certain inverse proportion with a unique art.
Save
Cyclodextrin inclusion compound Beta Cyclodextrin Polymer
Cyclodextrin Complex,Cyclodextrin Polymers,Cyclodextrin Inclusion Compound,Beta Cyclodextrin Polymers
Zhiyuan Biotchnology , http://www.zycydextrin.com